"cortico-limbic-striatal circuit" what is the definition? Pathway.?



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Original Article


Neuropsychopharmacology (2003) 28, 1760-1769, advance online publication, 23 July 2003;
doi:10.1038/sj.npp.1300225

Chronic Pubertal, but not Adult Chronic Cannabinoid Treatment Impairs Sensorimotor Gating, Recognition Memory, and the Performance contained by a Progressive Ratio Task in Adult Rats

Miriam Schneider and Michael Koch



Brain Research Institute, Department of Neuropharmacology, University of Bremen, Bremen, Germany

Correspondence: Dr M Schneider, Brain Research Institute, Department of Neuropharmacology, University of Bremen, PO Box 33 04 40, 28334 Bremen, Germany. Tel: +42 121 872 89; E-mail: miriam.schneider@uni-bremen.de

Received: 10 February 2003
Revised: 3 April 2003
Accepted: 12 May 2003




ABSTRACT



There is evidence from studies surrounded by humans and animals that a vulnerable term for chronic cannabinoid administration exists during unshakable phases of development. The present study tested the hypothesis that long-lasting interference of cannabinoids near the developing endogenous cannabinoid system during puberty causes obstinate behavioral alterations in grown rats. Chronic treatment with the synthetic cannabinoid agonist WIN 55,212-2 (WIN) (1.2 mg/kg) or vehicle be extended over 25 days either throughout the rats' puberty or for a similar time term in mature rats. The rats received 20 injections intraperitoneally (i.p.), which were not deliver regularly. Adult rats were tested for purpose recognition memory, see in a progressive ratio (PR) operant behavior project, locomotor activity, and prepulse inhibition (PPI) of the aural startle response (ASR). PPI was significantly disrupted with the sole purpose by chronic peripubertal cannabinoid treatment. This long-lasting PPI deficit was reversed by the acute regime of the dopamine antagonist haloperidol. Furthermore, we found deficits contained by recognition memory of pubertal-treated rats and these animals showed lower break points within a PR schedule, whereas food nouns and locomotion were not artificial. Adult chronic cannabinoid treatment had no effect on the behaviors tested. Therefore, we verbs that puberty in rats is a adjectives period beside respect to the adverse effects of cannabinoid treatment. Since PPI deficits, jib recognition memory impairments, and anhedonia/avolition are among the endophenotypes of schizophrenia, we propose chronic cannabinoid leadership during pubertal development as an animal model for some aspects of the etiology of schizophrenia.
I'm not sure what you're asking here, but I will embezzle a stab at it and hopefully you will have adequate information to ask a followup question.

It sounds resembling you are being asked a grill having to do near circuitry in the brain regulating exciting behavior.

The cortex (Latin: "bark of a tree") is the outer covering of the brain, where on earth much of the processing of higher-order sensory and motor information occurs.

The limbic system (French, name by Broca: "le grand lobe limbique", designation, "rim" or "edge") is the emotional portion of the brain. Papez' Circuit is the classical view of the limbic system: cingulate cortex to hippocampus to mammillary bodies to anterior nucleus of the thalamus to cingulate cortex (forming a big circle and defining the parts of the so-called limbic system).

"Striatum" refers within neuroscientist shorthand to the "corpus striatum", another name for the basal ganglion (better yet, the basal nuclei). They regulate motor output, as okay as having a poorly-understood but critical role surrounded by emotional behaviors. (These are what psychiatrists and brain scientists phone call "affective behaviors".)

It's the question "Pathway?" that I don't carry. Are you asking for specific pathways within the circuit?


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