How to multiply the toxic dose of the compound for which no previous mention is near?

lethal dose of the extract is to be calculated for giving to rats .so that dose could be decided for giving to rats .i am working on the antidiabetic activity. so please sustain me how to calculate the dose which can be done only after knowing the lethal dose.
If you are trying to determine the fatal dose, the method most commonly cited is know as LD-50 (which means Lethal Dose for 50% of subjects). Which means that you must give the subjects increasing amounts of the compound until you find the horizontal that kills half of them. Your question requests clarification; am I answering what you're asking, or am I off-base?

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