How long does an opiate (any of them) molecule occupy the binding site on a membrane receptor?

I understand that the 'lock and key' analogy is one of premier fundamental concepts underlying biology and biochemistry, and I understand how this works. However, I've never read anywhere just exactly how long a 'key' stays surrounded by the 'lock' and I assume there exists great variance depending on the molecule and target receptor. What variables influence the length of occupation? In general, how long does a ligand occupy it's binding site on a membrane receptor? I used opiate molecules beside their corresponding opioid receptors as a more specific example.
Answers:
Usually on the order of milliseconds. This will vary depending on the dissociation constant, but this is a general rule of thumb for transmitters.


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